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Article

Inactivation of the 7B2 inhibitory CT peptide depends on a functional furin cleavage site.

Journal of neurochemistry - 1 Oct 2001

Hwang J R, Lindberg I

Abstract excerpt

The eukaryotic subtilisin prohormone convertase 2 (PC2) is known to require in vivo exposure to the neuroendocrine protein 7B2 in order to produce an enzymatically active species capable of proteolytic action on prohormone substrates. In the present study, we examined the role of the pentabasic site within 27-kDa 7B2 in this process. We prepared two His-tagged recombinant 7B2s by overexpression in bacteria:...

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PMID: 11677272
DOI: 10.1046/j.1471-4159.2001.00594.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Inactivation of the 7B2 inhibitory CT peptide depends on a functional furin cleavage site.PMID 11677272Read ↗

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