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Article

Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation.

International journal of radiation biology - 1 Aug 1996

Sproston A R, Boyle J M, Heighway J, Birch J M, Scott D

Abstract excerpt

A group of adult skin fibroblast cultures from four individuals representing Li-Fraumeni families with different mutations in the p53 gene were found to be resistant to low dose-rate (0.011 Gy per min) 60Co radiation when compared with a control group of four cultures from normal individuals. The Li-Fraumeni fibroblasts, which could not be distinguished from controls after high dose rate (1.07 Gy per min)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8794843
DOI: 10.1080/095530096145139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation.PMID 8794843Read ↗

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Delayed chromosome changes in gamma-irradiated normal and Li-Fraumeni fibroblasts.Semantic proximity Read ↗

Radiation-induced G1 arrest is not defective in fibroblasts from Li-Fraumeni families without TP53 mutations.Semantic proximity Read ↗

Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families.Semantic proximity Read ↗

Aberrant p21WAF1-dependent growth arrest as the possible mechanism of abnormal resistance to ultraviolet light cytotoxicity in Li-Fraumeni syndrome fibroblast strains heterozygous for TP53 mutations.Semantic proximity Read ↗

Intrinsic radiosensitivity of normal human fibroblasts and lymphocytes after high- and low-dose-rate irradiation.Semantic proximity Read ↗

Cell cycle arrest defect in Li-Fraumeni Syndrome: a mechanism of cancer predisposition?Semantic proximity Read ↗

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