Differences in hepatic drug accumulation and enzyme induction after chronic amiodarone feeding of two rat strains: role of the hydroxylator phenotype?

doi:10.1111/j.1476-5381.1990.tb14650.x

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Article

Differences in hepatic drug accumulation and enzyme induction after chronic amiodarone feeding of two rat strains: role of the hydroxylator phenotype?

British journal of pharmacology - 1 Jan 1990

Pirovino M, Honegger U, Müller O, Zysset T, Küpfer A, Tinel M, Pessayre D

Abstract excerpt

1. It has previously been shown that the extent of hepatic phospholipidosis induced by chronic amiodarone treatment correlates with the degree of drug accumulation in liver tissue. 2. To investigate a possible influence of pharmacogenetic factors, biochemical and morphological investigations were carried out in two rat strains differing in debrisoquine hydroxylation. 3. Plasma and liver tissue concentrations of...

Topics

Amiodarone
Animals
Body Weight
Chromatography, Gas
Chromatography, High Pressure Liquid
Enzyme Induction
Female
Hydroxylation
Liver
Microscopy, Electron
Microsomes, Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organ Size

Pharmaceutical Preparations

Phenotype

Phospholipids

Rats

Rats, Inbred Strains

Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 2331573
DOI: 10.1111/j.1476-5381.1990.tb14650.x
PMCID: PMC1917520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2331573-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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