Article
Mutant female mice carrying a single mZP3 allele produce eggs with a thin zona pellucida, but reproduce normally.
Proceedings. Biological sciences - 22 Mar 1997
Wassarman P M, Qi H, Litscher E S
Abstract excerpt
The mouse egg zona pellucida (ZP) is composed of three glycoproteins, called mZP1-3. Disruption of the mZP3 gene by targeted mutagenesis yields mice that are homozygous (mZP3-/-) for the null mutation; although the mutant mice are viable, females are infertile and their eggs lack a ZP. On the oth...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.