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Article

Chromosome 7q35 and susceptibility to diabetic microvascular complications.

Journal of diabetes and its complications - 1 Jan 2000

Patel A, Hibberd M L, Millward B A, Demaine A G

Abstract excerpt

Aldose reductase (ALR2), the first enzyme of the polyol pathway, may plan an important role in the pathogenesis of diabetic microvascular complications. The gene coding for ALR2 has been localized to chromosome 7q35. Using an ALR2 probe in conjunction with the restriction endonuclease Bam-HI, we have investigated the ALR2 locus of 128 patients with type I diabetes. A significant decrease in the frequency of the...

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Identifiers

PMID: 8777332
DOI: 10.1016/1056-8727(95)00004-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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