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Article

Susceptibility to diabetic neuropathy in patients with insulin dependent diabetes mellitus is associated with a polymorphism at the 5' end of the aldose reductase gene.

Journal of neurology, neurosurgery, and psychiatry - 1 Feb 1998

Heesom A E, Millward A, Demaine A G

Abstract excerpt

OBJECTIVES: There is evidence that the polyol pathway is involved in the pathogenesis of diabetic neuropathy. Aldose reductase (ALR2) is the first and rate limiting enzyme of this pathway and recent studies have suggested that polymorphisms in and around the gene are associated with the developme...

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Identifiers

PMID: 9489533
DOI: 10.1136/jnnp.64.2.213
PMCID: PMC2169937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9489533-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Susceptibility to diabetic neuropathy in patients with insulin dependent diabetes mellitus is associated with a polymorphism at the 5' end of the aldose reductase gene.PMID 9489533Read ↗

Polymorphism in the 5′-End of the Aldose Reductase Gene Is Strongly Associated With the Development of Diabetic Nephropathy in Type I DiabetesSemantic proximity Read ↗

Polymorphisms of the aldose reductase gene and susceptibility to retinopathy in type 1 diabetes mellitus.Semantic proximity Read ↗

Polymorphisms of the aldose reductase gene and susceptibility to diabetic microvascular complications.Semantic proximity Read ↗

Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy.Semantic proximity Read ↗

Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes.Semantic proximity Read ↗

Aldose reductase gene polymorphisms and susceptibility to diabetic nephropathy in Type 1 diabetes mellitus.Semantic proximity Read ↗

Association of aldose reductase gene polymorphism (C-106T) in susceptibility of diabetic peripheral neuropathy among north Indian population.Semantic proximity Read ↗

Association of aldose reductase gene Z+2 polymorphism with reduced susceptibility to diabetic nephropathy in Caucasian Type 1 diabetic patients.Semantic proximity Read ↗

Aldose reductase inhibitors: therapeutic implications for diabetic complicationsSemantic proximity Read ↗

Association of an (A-C)n dinucleotide repeat polymorphic marker at the 5'-region of the aldose reductase gene with retinopathy but not with nephropathy or neuropathy in Japanese patients with Type 2 diabetes mellitus.Semantic proximity Read ↗

Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes.Semantic proximity Read ↗

Association of the p22phox component of NAD(P)H oxidase with susceptibility to diabetic nephropathy in patients with type 1 diabetes.Semantic proximity Read ↗

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