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Article

Aldose reductase gene is associated with diabetic macroangiopathy in Japanese Type 2 diabetic patients.

Diabetic medicine : a journal of the British Diabetic Association - 1 Aug 2006

Watarai A, Nakashima E, Hamada Y, Watanabe G, Naruse K, Miwa K, Kobayashi Y, Kamiya H, Nakae M, Hamajima N, Sekido Y, Niwa T, Oiso Y, Nakamura J

Abstract excerpt

AIMS: The aldose reductase (AR) gene, a rate-limiting enzyme of the polyol pathway, has been investigated as a candidate gene in determining susceptibility to diabetic microangiopathy. However, the association of the AR gene with diabetic macroangiopathy has not been investigated. Therefore, the present study was conducted to determine whether genetic variations of AR may determine susceptibility to diabetic...

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Identifiers

PMID: 16911628
DOI: 10.1111/j.1464-5491.2006.01946.x
PMCID: PMC1619898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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