Article
Biosynthetic and growth abnormalities are associated with high-level expression of CFTR in heterologous cells.
The American journal of physiology - 1 Jan 1996
Schiavi S C, Abdelkader N, Reber S, Pennington S, Narayana R, McPherson J M, Smith A E, Hoppe H, Cheng S H
Abstract excerpt
An inducible gene amplification system was utilized to study the effects of overexpression of cystic fibrosis transmembrane conductance regulator (CFTR) in vitro. BTS, a monkey kidney cell line expressing a temperature-sensitive simian virus 40 (SV-40) large T antigen was stably transfected at the nonpermissive temperature with a plasmid containing an SV-40 origin of replication and the cDNA for either the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.