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Article

Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time

1 Oct 1996

Abstract excerpt

The efficiency of adenovirus-mediated gene transfer to airway epithelia will be an important factor in determining whether recombinant adenoviruses can be developed as vectors for transferring cystic fibrosis transmembrane conductance regulator (CFTR) cDNA to patients with cystic fibrosis. Current understanding of the biology of CF lung disease suggests that vectors should express transgene in mature, ciliated...

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Identifiers

PMID: 8794344
DOI: 10.1128/jvi.70.10.6994-7003.1996

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