Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-6, IL-6 receptor, and IL-6 nuclear factor gene expression in Paget's disease.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 1994

Hoyland J A, Freemont A J, Sharpe P T

Abstract excerpt

The cytokine interleukin-6 (IL-6) is considered an important regulator of bone cell function and may play a central role in bone disease states characterized by increased bone remodeling, such as Paget's disease. Indeed, recent in vitro data suggest that IL-6 may be an autocrine/paracrine factor for pagetic osteoclasts. However, its expression and role in vivo are not known. Using in situ hybridization we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to In Situ Hybridization

Share to Interleukin-6

Share to Nuclear Proteins

Share to Phenotype

Share to RNA, Messenger

Source

Identifiers

PMID: 8154312
DOI: 10.1002/jbmr.5650090111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-6, IL-6 receptor, and IL-6 nuclear factor gene expression in Paget's disease.PMID 8154312Read ↗

Differential Gene Expression in Cultured Osteoblasts and Bone Marrow Stromal Cells From Patients With Paget's Disease of BoneSemantic proximity Read ↗

Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone.Semantic proximity Read ↗

Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss.Semantic proximity Read ↗

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation.Semantic proximity Read ↗

Role of interleukin-6 in macrophage functionSemantic proximity Read ↗

Complex regulation of tartrate-resistant acid phosphatase (TRAP) expression by interleukin 4 (IL-4): IL-4 indirectly suppresses receptor activator of NF-kappaB ligand (RANKL)-mediated TRAP expression but modestly induces its expression directly.Semantic proximity Read ↗

Dogs, distemper and Paget's disease.Semantic proximity Read ↗

A crucial role of interleukin-6 in the pathogenesis of thyrotoxicosis-related disturbances of bone turnover in mice.Semantic proximity Read ↗

Enhanced Expression of Osteocalcin mRNA in Human Osteoarthritic Trabecular Bone of the Proximal Femur Is Associated with Decreased Expression of Interleukin-6 and Interleukin-11 mRNASemantic proximity Read ↗

PCR detection of cytokines in normal human and pagetic osteoblast-like cells.Semantic proximity Read ↗

Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene.Semantic proximity Read ↗

Bone marrow mononuclear cells from patients with Paget's disease contain measles virus nucleocapsid messenger ribonucleic acid that has mutations in a specific region of the sequence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.