Article
The MDR phenotype in hematologic malignancies: prognostic relevance and future perspectives.
Annals of hematology - 1 Mar 1996
Hegewisch-Becker S, Hossfeld D K
Abstract excerpt
The multidrug resistant (MDR) phenotype has been suspected as a major cause of treatment failure in hematologic malignancies. Numerous studies have investigated the expression of the MDR1 gene product, P-glycoprotein, in leukemia, lymphoma and myeloma. Studies in myelogenous leukemia and myeloma have so far provided best evidence for a significant correlation between P-glycoprotein expression and response to...
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