Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human.

doi:10.1002/eji.1830260820

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Article

Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human.

European journal of immunology - 1 Aug 1996

Küppers R, Hajadi M, Plank L, Rajewsky K, Hansmann M L

Abstract excerpt

Five cases of monocytoid B cell lymphoma (MBCL) were analyzed for somatic mutations in the rearranged V region genes. Somatic mutations were found in four of the five cases, whereas one unusual CD5+ lymphoma harbored unmutated V region genes. Since somatic mutations are introduced into V region g...

Topics

Amino Acid Sequence
B-Lymphocytes
Base Sequence
Enhancer Elements, Genetic
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Lymphoma, B-Cell
Molecular Sequence Data

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Mutation

Sequence Deletion

Source

Open in PubMed

Identifiers

PMID: 8765023
DOI: 10.1002/eji.1830260820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8765023-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.