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Article

Variation in topoisomerase I gene copy number as a mechanism for intrinsic drug sensitivity.

British journal of cancer - 1 Aug 1996

McLeod H L, Keith W N

Abstract excerpt

DNA topoisomerase I (topo I) is the principle target for camptothecin and its derivatives such as SN38. Levels of topo I expression vary widely between and within tumour types and the basis for this is poorly understood. We have used fluorescence in situ hybridisation to detect the topo I locus in a panel of breast and colon cancer cell lines. This approach has identified a range of topo I gene copies from 1 to 6...

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Identifiers

PMID: 8761363
DOI: 10.1038/bjc.1996.394
PMCID: PMC2074660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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