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Topoisomerase 1(<i>TOP1</i>) gene copy number in stage III colorectal cancer patients and its relation to prognosis

11 Oct 2012

Abstract excerpt

PURPOSE: A Topoisomerase 1 (Top1) poison is frequently included in the treatment regimens for metastatic colorectal cancer (mCRC). However, no predictive biomarkers for Top1 poisons are available. We here report a study on the TOP1 gene copy number in CRC patients and its association with patient prognosis and tumor cell proliferation. EXPERIMENTAL DESIGN: The study included TOP1 and CEN-20 fluorescence in situ...

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PMID: 23110915
DOI: 10.1016/j.molonc.2012.09.001

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Topoisomerase 1(<i>TOP1</i>) gene copy number in stage III colorectal cancer patients and its relation to prognosisPMID 23110915Read ↗

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