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Article

Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5.

Cancer genomics & proteomics - 1 Jan 2000

Kjeldsen Eigil, Nielsen Christine J F, Roy Amit, Tesauro Cinzia, Jakobsen Ann-Katrine, Stougaard Magnus, Knudsen Birgitta R

Abstract excerpt

Acquisition of resistance to topoisomerase I (TOP1)-targeting camptothecin (CPT) derivatives is a major clinical problem. Little is known about the underlying chromosomal and genomic mechanisms. We characterized the CPT-K5 cell line expressing mutant CPT-resistant TOP1 and its parental T-cell derived acute lymphoblastic leukemia CPT-sensitive RPMI-8402 cell line by karyotyping and molecular genetic methods,...

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Identifiers

PMID: 29496689
DOI: 10.21873/cgp.20068
PMCID: PMC5892604

Genes

TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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