Article
Karyotypic variation between independently cultured strains of the cell line MCF-7 identified by multicolour fluorescence in situ hybridization.
International journal of oncology - 1 Mar 2002
Bahia H, Ashman J N E, Cawkwell L, Lind M, Monson J R T, Drew P J, Greenman J
Abstract excerpt
The breast cancer cell line MCF-7 is a widely used model in breast cancer research however a number of conflicting reports have been published regarding its biological properties. We hypothesised that there will be significant in vitro mutation and genotypic evolution over time in this cell line. To assess the genetic divergence of MCF-7 at the chromosomal level, we analysed MCF-7 cell lines grown independently...
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