TELOMERE REDUCTION IN SCLERODERMA PATIENTS: A POSSIBLE CAUSE FOR CHROMOSOMAL INSTABILITY

Abstract excerpt

We have hypothesized that the chromosomal instability observed in scleroderma patients and their family members may result from the loss of long stretches of the telomeric repeat which is found at the ends of all linear chromosomes. We examined the telomere lengths in scleroderma (SSc) patients (n = 43), their family members (n = 182) and in age-matched controls (n = 96) using restriction fragment length...

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