Article
Immunodominance, competition and evolution in immunological responses to helminth parasite antigens.
Parasitology - 1 Aug 1996
Austin D J, Anderson R M
Abstract excerpt
The paper describes the development and analysis of a mathematical framework for the study of the within-host population dynamics of the interaction between macroparasites and the human immune system. Simple models of this interaction based on the proliferation of T cell clones specific to parasite antigen, and the impact of clonal expansion on parasite survival, capture the basic features of age-related changes...
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