Article
Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa.
PloS one - 1 Jan 2014
Bandeiras Cátia, Trovoada Maria Jesus, Gonçalves Lígia A, Marinho Cláudio R F, Turner Louise, Hviid Lars, Penha-Gonçalves Carlos, Gomes M Gabriela M
Abstract excerpt
After remarkable success of vector control campaigns worldwide, concerns about loss of immunity against Plasmodium falciparum due to lack of exposure to the parasite are relevant since an increase of severe cases in less immune individuals is expected. We present a mathematical model to investigate the impact of reducing exposure to the parasite on the immune repertoire against P. falciparum erythrocyte membrane...
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