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Article

Generation and characterization of fully human monoclonal antibodies against human Orai1 for autoimmune disease.

The Journal of pharmacology and experimental therapeutics - 1 May 2013

Lin Fen-Fen, Elliott Robin, Colombero Anne, Gaida Kevin, Kelley Laura, Moksa Angelica, Ho Shu-Yin, Bykova Ekaterina, Wong Min, Rathanaswami Palaniswami, Hu Sylvia, Sullivan John K, Nguyen Hung Q, McBride Helen J

Abstract excerpt

Calcium entry into T cells following antigen stimulation is crucial for nuclear factor of activated T cells (NFAT)-mediated T cell activation. The movement of calcium is mediated by calcium release-activated calcium (CRAC) channels. There are two key components of this channel: Orai1 is the pore-forming subunit located in the plasma membrane, and stromal interaction molecule 1 (STIM1) functions as a Ca(2+) sensor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23475901
DOI: 10.1124/jpet.112.202788

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Generation and characterization of fully human monoclonal antibodies against human Orai1 for autoimmune disease.PMID 23475901Read ↗

Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity.Semantic proximity Read ↗

Immunodeficiency due to mutations in ORAI1 and STIM1.Semantic proximity Read ↗

Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell FunctionSemantic proximity Read ↗

A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and TranscriptionSemantic proximity Read ↗

ORAI1 mutations abolishing store-operated Ca2+ entry cause anhidrotic ectodermal dysplasia with immunodeficiency.Semantic proximity Read ↗

Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.Semantic proximity Read ↗

[Immunodeficiencies and pathologies associated with mutations in STIM/ORAI, a membrane complex in the heart of calcium signalling].Semantic proximity Read ↗

Orai1 is an essential pore subunit of the CRAC channel.Semantic proximity Read ↗

Immunodeficiency due to defects in store-operated calcium entry.Semantic proximity Read ↗

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.Semantic proximity Read ↗

Diseases caused by mutations in ORAI1 and STIM1.Semantic proximity Read ↗

Combined immunodeficiency due to a homozygous mutation in ORAI1 that deletes the C-terminus that interacts with STIM 1.Semantic proximity Read ↗

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