Article
Adhesiveness of beta5 integrin variant lacking FNK767-769 is similar to that of the prototype containing FNKFNK764-769.
Cell biology international - 1 Jul 2005
Kawahara Ei, Saito Ayumi, Kobayashi Jun, Maenaka Shiori, Minamoto Toshinari, Imai Miwa Akasofu, Oda Yoshio
Abstract excerpt
Little is known about the functions of two different beta5 integrins: repeated-FNK (FNKFNK764-769) and single-FNK (FNK764-766) amino acid sequences in the cytoplasmic domain. We examined whether they occurred as germ line mutations or somatic mutations associated with neoplastic transformation, and whether there were functional alterations. Out of six cultured cell lines, only KATO-III cells had the single-FNK...
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