Article
Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4.
American journal of human genetics - 1 Sept 1996
Rao V S, Cupples A, van Duijn C M, Kurz A, Green R C, Chui H, Duara R, Auerbach S A, Volicer L, Wells J, van Broeckhoven C, Growdon J H, Haines J L, Farrer L A
Abstract excerpt
Apolipoprotein E (APOE) genotype is the single most important determinant to the common form of Alzheimer disease (AD) yet identified. Several studies show that family history of AD is not entirely accounted for by APOE genotype. Also, there is evidence for an interaction between APOE genotype and gender. We carried out a complex segregation analysis in 636 nuclear families of consecutively ascertained and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.