Article
Chromosome 22 markers demonstrate transmission disequilibrium with schizophrenia.
Psychiatric genetics - 1 Jan 1995
Vallada H, Curtis D, Sham P C, Murray R M, McGuffin P, Nanko S, Gill M, Owen M, Collier D A
Abstract excerpt
Previously we reported evidence for genetic linkage between markers on chromosome 22q12 and schizophrenia in 23 multiply affected pedigrees. As part of further investigation of this region, we have applied the transmission disequilibrium test (TDT) to the genotype data. The TDT is a test for both linkage and linkage disequilibrium, and is based on the unequal probability of transmission of two different marker...
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