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<i>Helicobacter pylori</i> Vacuolating Cytotoxin Inhibits T Lymphocyte Activation

21 Aug 2003

Abstract excerpt

Helicobacter pylori (Hp) vacuolating cytotoxin VacA induces cellular vacuolation in epithelial cells. We found that VacA could efficiently block proliferation of T cells by inducing a G1/S cell cycle arrest. It interfered with the T cell receptor/interleukin-2 (IL-2) signaling pathway at the level of the Ca2+-calmodulin-dependent phosphatase calcineurin. Nuclear translocation of nuclear factor of activated T...

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PMID: 12934009
DOI: 10.1126/science.1086871

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