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THE PATHOGENESIS OF<i>HELICOBACTER PYLORI</i>–INDUCED GASTRO-DUODENAL DISEASES

1 Feb 2006

Abstract excerpt

Helicobacter pylori is the main cause of peptic ulceration, distal gastric adenocarcinoma, and gastric lymphoma. Only 15% of those colonized develop disease, and pathogenesis depends upon strain virulence, host genetic susceptibility, and environmental cofactors. Virulence factors include the cag pathogenicity island, which induces proinflammatory, pro-proliferative epithelial cell signaling; the cytotoxin VacA,...

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PMID: 18039108
DOI: 10.1146/annurev.pathol.1.110304.100125

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