Article
Drug-induced reversion of progression phenotype is accompanied by reversion of AP-1 phenotype in JB6 cells.
In vitro cellular & developmental biology. Animal - 1 Apr 1996
Lavrovsky V, Dong Z, Ma W Y, Colburn N
Abstract excerpt
Transformed JB6 cells can be stably reverted to nontransformed phenotype by AP-1 inhibiting gluccorticoid fluocinolone (FA) and cAMP elevator forskolin (FN), yielding stable revertants of promotion resistant (P-) and promotion sensitive (P+) phenotypes. AP-1 activity of nontransformed P- and P+ revertant clones was decreased under a variety of experimental conditions compared with their transformed counterparts....
Topics
- 3T3 Cells
- Animals
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Clone Cells
- Colforsin
- Epidermal Growth Factor
- Fluocinolone Acetonide
- Glucocorticoids
- Mice