Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic activation of Gi-2 protein, the product of a putative protooncogene, mediates tumor promotion in vitro.

Carcinogenesis - 1 Dec 1992

Harbers M, Borowski P, Fanick W, Lengyel H, Buck F, Hinsch K D, Hilz H

Abstract excerpt

Promotion of 'initiated' JB6 epidermal cells to the tumor phenotype can be effected by 12-O-tetradecanoylphorbol-13-acetate treatment, by stimulation of epidermal growth factor (EGF) receptor activity with EGF or transforming growth factor alpha and by exposure to the isoquinoline derivative H7. When these cells were incubated with pertussis toxin (PTX), induction of anchorage-independent growth by all four...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Molecular Sequence Data

Share to Mutation

Share to Phenotype

Source

Identifiers

PMID: 1473250
DOI: 10.1093/carcin/13.12.2403

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Epigenetic activation of Gi-2 protein, the product of a putative protooncogene, mediates tumor promotion in vitro.PMID 1473250Read ↗

Grafting assay distinguishes promotion sensitive from promotion resistant JB6 cells.Semantic proximity Read ↗

Drug-induced reversion of progression phenotype is accompanied by reversion of AP-1 phenotype in JB6 cells.Semantic proximity Read ↗

Papillomas induced by initiation-promotion differ from those induced by carcinogen alone.Semantic proximity Read ↗

Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently.Semantic proximity Read ↗

Gene regulation and genetic susceptibility to neoplastic transformation: AP-1 and p80 expression in JB6 cells.Semantic proximity Read ↗

PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells.Semantic proximity Read ↗

A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells.Semantic proximity Read ↗

Mutant alpha subunit of Gz transforms Swiss 3T3 cells.Semantic proximity Read ↗

Only a subset of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin papillomas are promotable by benzoyl peroxide.Semantic proximity Read ↗

"Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells".Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.