Article
Epigenetic activation of Gi-2 protein, the product of a putative protooncogene, mediates tumor promotion in vitro.
Carcinogenesis - 1 Dec 1992
Harbers M, Borowski P, Fanick W, Lengyel H, Buck F, Hinsch K D, Hilz H
Abstract excerpt
Promotion of 'initiated' JB6 epidermal cells to the tumor phenotype can be effected by 12-O-tetradecanoylphorbol-13-acetate treatment, by stimulation of epidermal growth factor (EGF) receptor activity with EGF or transforming growth factor alpha and by exposure to the isoquinoline derivative H7. When these cells were incubated with pertussis toxin (PTX), induction of anchorage-independent growth by all four...
Topics
- Adrenal Gland Neoplasms
- Amino Acid Sequence
- Animals
- Cell Transformation, Neoplastic
- Cells, Cultured
- Epidermal Growth Factor
- Female
- GTP-Binding Proteins
- Mice
- Molecular Sequence Data
- Mutation