Article
Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase.
Genes & development - 1 Jul 1992
Cairns B R, Ramer S W, Kornberg R D
Abstract excerpt
The signal transduction pathway that mediates the response of haploid yeast cells to peptide mating pheromones involves several components including the protein kinases STE7 and STE11. We have isolated and characterized a dominant allele of the STE11 gene and have demonstrated that expression of...
Topics
- Alleles
- Base Sequence
- DNA, Fungal
- Fungal Proteins
- Genes, Fungal
- Immunoblotting
- MAP Kinase Kinase Kinases
- Mating Factor
- Mitogen-Activated Protein Kinase Kinases
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Peptides
- Phenotype
- Pheromones
- Phosphorylation
- Protein Kinases
- Protein-Tyrosine Kinases