Article
Revertant analysis of J-K mutations in the encephalomyocarditis virus internal ribosomal entry site detects an altered leader protein.
Journal of virology - 1 Sept 1996
Hoffman M A, Palmenberg A C
Abstract excerpt
The internal ribosomal entry site (IRES) of picornaviruses consists of various sequence and structural elements that collectively impart translational function to the genome. By engineering substitution and deletion mutations into the J-K elements of the encephalomyocarditis virus IRES, translati...
Topics
- Animals
- Base Sequence
- Binding Sites
- DNA Primers
- Defective Viruses
- Encephalomyocarditis virus
- Models, Structural
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Nucleic Acid Conformation
- Phenotype
- Point Mutation
- Protein Biosynthesis
- Protein Sorting Signals
- RNA, Viral
- Reticulocytes
- Ribosomes
- Transcription, Genetic