Molecular mechanisms of clarithromycin resistance in Mycobacterium avium: observation of multiple 23S rDNA mutations in a clonal population.

doi:10.1093/infdis/174.2.354

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Article

Molecular mechanisms of clarithromycin resistance in Mycobacterium avium: observation of multiple 23S rDNA mutations in a clonal population.

The Journal of infectious diseases - 1 Aug 1996

Meier A, Heifets L, Wallace R J, Zhang Y, Brown B A, Sander P, Böttger E C

Abstract excerpt

The peptidyltransferase region of the 23S rRNA gene (the probable target site for the macrolides) was investigated in blood isolates of Mycobacterium avium recovered from 38 patients before and after the development of clarithromycin resistance. Point mutations were identified in 100% of the 74 r...

Topics

Base Sequence
Clarithromycin
DNA, Ribosomal
Drug Resistance, Microbial
Electrophoresis, Gel, Pulsed-Field
Humans
Molecular Sequence Data
Mutation
Mycobacterium avium Complex
Mycobacterium avium-intracellulare Infection
Polymerase Chain Reaction
RNA, Ribosomal, 23S
Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 8699066
DOI: 10.1093/infdis/174.2.354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8699066-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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