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Article

Molecular basis of clarithromycin-resistance in Mycobacterium avium intracellulare complex.

Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Jan 2000

Jamal M A, Maeda S, Nakata N, Kai M, Fukuchi K, Kashiwabara Y

Abstract excerpt

Nucleotide sequences of domain V and domain II regions of the 23S rRNA gene were determined in both in vitro-made mutants and clinical isolates of Mycobacterium avium and M. intracellulare conferring clarithromycin-resistance. All laboratory-made mutants showed high level resistance to clarithromycin (> 150 micrograms ml-1) and mutation at position 2058 (cognate with Escherichia coli base) in domain V region. In...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10897378
DOI: 10.1054/tuld.1999.0227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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