Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of mutations in 23S rRNA gene of clarithromycin-resistant Mycobacterium intracellulare.

Antimicrobial agents and chemotherapy - 1 Feb 1994

Meier A, Kirschner P, Springer B, Steingrube V A, Brown B A, Wallace R J, Böttger E C

Abstract excerpt

Clarithromycin is a potent macrolide that has been used for treating infections with nontuberculous mycobacteria. Pairs of susceptible and resistant Mycobacterium intracellulare strains were obtained from patients with chronic pulmonary M. intracellulare infections undergoing monotherapy with cla...

Topics

Base Sequence
Clarithromycin
Drug Resistance, Microbial
Genes, Bacterial
Humans
Molecular Sequence Data
Mutation
Mycobacterium avium Complex
Nucleic Acid Conformation
RNA, Ribosomal, 23S

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 8192472
DOI: 10.1128/AAC.38.2.381
PMCID: PMC284463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8192472-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of mutations in 23S rRNA gene of clarithromycin-resistant Mycobacterium intracellulare.PMID 8192472Read ↗

PCR-Based Rapid Identification System Using Bridged Nucleic Acids for Detection of Clarithromycin-Resistant Mycobacterium avium-M. intracellulare Complex Isolates.Semantic proximity Read ↗

Molecular mechanisms of clarithromycin resistance in Mycobacterium avium: observation of multiple 23S rDNA mutations in a clonal population.Semantic proximity Read ↗

Molecular basis of clarithromycin-resistance in Mycobacterium avium intracellulare complex.Semantic proximity Read ↗

Methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible.Semantic proximity Read ↗

Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessusSemantic proximity Read ↗

Noncanonical mutations in ribosome nascent peptide exit tunnel confer clarithromycin resistance in Mycobacterium abscessus complex.Semantic proximity Read ↗

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.Semantic proximity Read ↗

Single and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit.Semantic proximity Read ↗

Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori.Semantic proximity Read ↗

Detection and quantification of macrolide resistance mutations at positions 2058 and 2059 of the 23S rRNA gene by pyrosequencing.Semantic proximity Read ↗

23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22.Semantic proximity Read ↗

Identification of a mutation associated with erythromycin resistance in Bordetella pertussis: implications for surveillance of antimicrobial resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.