Article
Acquired resistance in Mycobacterium avium complex strains isolated from AIDS patients and beige mice during treatment with clarithromycin.
The Journal of antimicrobial chemotherapy - 1 Jul 1995
Doucet-Populaire F, Truffot-Pernot C, Grosset J, Jarlier V
Abstract excerpt
Clarithromycin has been reported to select clarithromycin resistant mutants of Mycobacterium avium complex (MAC) during treatment with clarithromycin in AIDS patients and beige mice. We selected resistant mutants in vitro at a frequency of 5 x 10(-9). Clarithromycin resistant strains of MAC isola...
Topics
- Acquired Immunodeficiency Syndrome
- Animals
- Anti-Bacterial Agents
- Base Sequence
- Clarithromycin
- Drug Resistance, Microbial
- Erythromycin
- Humans
- Mice
- Mice, Inbred Strains
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Mycobacterium avium Complex
- Mycobacterium avium-intracellulare Infection
- Peptidyl Transferases
- RNA, Messenger
- Ribosomes