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Multifaceted effects of galU deletion on phenotype and virulence of Pseudomonas aeruginosa in vitro and in vivo.

Virulence - 1 Dec 2026

Yu Jie, Wang Jinying, Yang Yan, Sun Lang, Hu Xinxin, Nie Tongying, Yang Xinyi, Wang Xiukun, Li Congran, You Xuefu

Abstract excerpt

Pseudomonas aeruginosa is a widespread Gram-negative opportunistic pathogen in environmental and hospital settings, frequently causing respiratory diseases such as cystic fibrosis (CF), chronic obstructive pulmonary disorder (COPD), and ventilator-associated pneumonia. In our previous study, a galU-deleted clinical P. aeruginosa was found to exhibit increased susceptibility to polymyxins. The galU gene plays an...

Topics

Pseudomonas aeruginosa
Virulence
Animals
Pseudomonas Infections
Anti-Bacterial Agents
Gene Deletion
Bacterial Proteins
Phenotype
O Antigens
Polymyxins
Quorum Sensing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

Mice

CRISPR-Cas Systems

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Identifiers

PMID: 42482463
DOI: 10.1080/21505594.2026.2707803
PMCID: PMC13432885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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