Article
Amelioration of the behavioral phenotype in genetically ataxic mice through bilateral intracerebellar grafting of fetal Purkinje cells.
Cell transplantation - 1 Jan 2000
Triarhou L C, Zhang W, Lee W H
Abstract excerpt
We have previously applied neural grafting to "Purkinje cell degeneration" mutant mice (gene symbol pcd, mouse chromosome 13), a model of recessively inherited cerebello-olivary atrophy, to create appropriate interactions between wild-type and mutant cells in elucidating gene effects on the invol...
Topics
- Animals
- Ataxia
- Behavior, Animal
- Brain Tissue Transplantation
- Cerebellum
- Disease Models, Animal
- Fetal Tissue Transplantation
- Graft Survival
- Homozygote
- Immunohistochemistry
- Locomotion
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Phenotype
- Purkinje Cells