Unique cerebellar phenotype combining granule and Purkinje cell loss: morphological evidence for weaver* pcd double mutant mice.

doi:10.1007/BF01187132

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Article

Unique cerebellar phenotype combining granule and Purkinje cell loss: morphological evidence for weaver* pcd double mutant mice.

Journal of neurocytology - 1 Jan 1991

Ghetti B, Triarhou L C, Alyea C J, Dlouhy S R, Karn R C

Abstract excerpt

Weaver (wv/wv) mutant mice lose most granule cells of the cerebellum during the first 2 weeks of postnatal life; 'Purkinje cell degeneration' (pcd/pcd) mutants lose virtually all Purkinje cells between postnatal days 17 and 45. Both these neurological mutations are autosomal recessive. We designed a breeding protocol that, in theory, should result in the production of mice with a doubly mutant, wv/wv*pcd/pcd,...

Topics

Aging
Animals
Biomarkers
Calcium-Binding Proteins
Cerebellar Cortex
Cerebellum
Crosses, Genetic
Cytoplasmic Granules
Female
Genotype
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Neurologic Mutants

Microscopy, Electron

Phenotype

Purkinje Cells

Source

Open in PubMed

Identifiers

PMID: 2027034
DOI: 10.1007/BF01187132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2027034-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Unique cerebellar phenotype combining granule and Purkinje cell loss: morphological evidence for weaver* pcd double mutant mice.PMID 2027034Read ↗

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