Article
Anterior cingulate cortical transplantation in transgenic Huntington's disease mice.
Brain research bulletin - 1 Jan 2000
van Dellen A, Deacon R, York D, Blakemore C, Hannan A J
Abstract excerpt
Huntington's disease (HD) is an autosomal dominant disorder involving progressive neurodegeneration of the corpus striatum and cerebral cortex. Transgenic mice, in which exon 1 of the human HD gene with an expanded trinucleotide repeat is expressed, develop a neurodegenerative syndrome that closely models human HD. Transplantation of wild-type donor cortex into the anterior cingulate cortex of neonatal HD mice...
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