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Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy

19 May 2021

Abstract excerpt

Photodynamic therapy (PDT) is a clinically approved cancer therapy of low invasiveness. The therapeutic procedure involves administering a photosensitizing drug (PS), which is then activated with monochromatic light of a specific wavelength. The photochemical reaction produces highly toxic oxygen species. The development of resistance to PDT in some cancer cells is its main limitation. Several mechanisms are...

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PMID: 34044336
DOI: 10.1016/j.dnarep.2021.103136

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