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Article

Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate.

Biochemistry - 1 Mar 1994

Carroll S S, Geib J, Olsen D B, Stahlhut M, Shafer J A, Kuo L C

Abstract excerpt

HIV-1 reverse transcriptase can catalyze the addition of either azidothymidine monophosphate (AZTMP) or thymidine monophosphate (dTMP) to a primer strand opposite template adenosine bases. The ratio of incorporation of AZTMP to dTMP as catalyzed by HIV-1 reverse transcriptase has been determined to be 0.4 using an RNA-DNA duplex substrate prepared from oligonucleotides with sequences taken from the HIV-1 genome...

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Identifiers

PMID: 7509634
DOI: 10.1021/bi00174a018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate.PMID 7509634Read ↗

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