Article
Sensitivity of HIV-1 reverse transcriptase and its mutants to inhibition by azidothymidine triphosphate.
Biochemistry - 1 Mar 1994
Carroll S S, Geib J, Olsen D B, Stahlhut M, Shafer J A, Kuo L C
Abstract excerpt
HIV-1 reverse transcriptase can catalyze the addition of either azidothymidine monophosphate (AZTMP) or thymidine monophosphate (dTMP) to a primer strand opposite template adenosine bases. The ratio of incorporation of AZTMP to dTMP as catalyzed by HIV-1 reverse transcriptase has been determined...
Topics
- Antiviral Agents
- Base Sequence
- DNA Primers
- Dideoxynucleotides
- Diphosphates
- HIV Reverse Transcriptase
- HIV-1
- Hydrolysis
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- RNA-Directed DNA Polymerase
- Reverse Transcriptase Inhibitors
- Substrate Specificity
- Templates, Genetic
- Thymidine Monophosphate
- Thymine Nucleotides
- Zidovudine