Article
Composite likelihood modeling of neighboring site correlations of DNA sequence substitution rates.
Statistical applications in genetics and molecular biology - 1 Jan 2009
Deng Ling, Moore Dirk F
Abstract excerpt
Sequence data from a series of homologous DNA segments from related organisms are typically polymorphic at many sites, and these polymorphisms are the result of evolutionary processes. Such data may be used to estimate the substitution rates as well as the variability of these rates. Careful characterization of the distribution of this variation is essential for accurate estimation of evolutionary distances and...
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