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Article

Nonlinear kinetics after high-dose omeprazole caused by saturation of genetically variable CYP2C19.

Hepatology (Baltimore, Md.) - 1 Jun 1996

Rost K L, Roots I

Abstract excerpt

Nonlinear kinetics of omeprazole and its metabolites were investigated after treatment with repeated high doses. Extensive metabolizers relating to cytochrome P450 2C19 (CYP2C19) activity received for 1 week either omeprazole at 40 mg/d (n = 14) or 60 mg/d omeprazole twice daily (n = 8). Five poor metabolizers (PMs) received 40 mg/d for 1 week. Comparison of omeprazole plasma kinetics between extensive...

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Identifiers

PMID: 8675169
DOI: 10.1002/hep.510230628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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