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Article

Iterative optimization of high-affinity protease inhibitors using phage display. 2. Plasma kallikrein and thrombin.

Biochemistry - 18 Jun 1996

Markland W, Ley A C, Ladner R C

Abstract excerpt

As discussed in the accompanying paper [Markland, W., Ley, A. C., & Ladner, R. C. (1996) Biochemistry 35, 8045-8057], we generated libraries from the first Kunitz domain of human lipoprotein-associated coagulation inhibitor (LACI-D1) using multivalent M13 III display and derived potent inhibitors of human plasmin (PLA) by iterative variegation and selection. Here, we show that high-affinity, high-specificity...

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PMID: 8672510
DOI: 10.1021/bi952629y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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