Article
[Low incidence of mutations in codon 12 of the c-K-ras gene in bladder cancer].
Actas urologicas espanolas - 1 Sept 1995
Ejarque M J, Villanueva A, Chechile G, Regalado R, Errando C, Algaba F, Capella G, Lluis F, Villavicencio H, Vicente J
Abstract excerpt
During vesical carcinogenesis a variety of genetic alterations such as oncogene mutation or loss of suppressor genes have been detected. Codon 12 mutation of the c-K-ras gene has been seen with a high frequency in several human neoplasias but its participation in the development of vesical cancers has not been fully dilucidated. Using the DNA restriction fragments polymorphism (RFLP) technique enhanced by a...
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