Article
Vitamin D-mediated gene regulation in phenotypically defined human B cell subpopulations.
Endocrinology - 1 Sept 2000
Morgan J W, Kouttab N, Ford D, Maizel A L
Abstract excerpt
Isolation of distinct subpopulations of density-fractionated normal human B lymphocytes reveals that the requirements for up-regulation of the vitamin D receptor (VDR) and initiation of 1alpha,25-dihydroxyvitamin D3 [1alpha,25-(OH)2D3]-mediated genomic trans-activation are dependent upon the state of cellular activation. The kinetics of the response differ widely among these B cell subpopulations. However, these...
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