Article
Prostaglandin E2 regulates vitamin D receptor expression, vitamin D-24-hydroxylase activity and cell proliferation in an adherent human myeloid leukemia cell line (Ad-HL60).
Prostaglandins & other lipid mediators - 1 May 1999
Smith S J, Green L M, Hayes M E, Mawer E B
Abstract excerpt
The effects of prostaglandin E2, forskolin, and phorbol 12-myristate 13-acetate on cell proliferation, cell surface antigen expression, vitamin D-24-hydroxylase activity and vitamin D receptor (VDR) expression have been studied in an adherent variant (Ad-HL60) of the human HL60 promyelomonocytic leukemia cell line. Ad-HL60 cells have a more differentiated phenotype than the nonadherent HL60 cells from which they...
Topics
- 24,25-Dihydroxyvitamin D 3
- Antigens, CD
- Calcitriol
- Cell Division
- Colforsin
- Cyclic AMP
- Cytochrome P-450 Enzyme System
- Dinoprostone
- Flow Cytometry
- HL-60 Cells
- Humans
- Phenotype
- Receptors, Calcitriol
- Steroid Hydroxylases