Article
Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-kB, in endothelial cells: species and vascular bed diversity.
Journal of biomechanics - 1 Dec 1995
Du W, Mills I, Sumpio B E
Abstract excerpt
Recent studies demonstrate that cyclic strain stimulates protein kinase C in bovine aortic endothelial cells (BAEC) as well as the induction of immediate early genes and the transcription factor activator protein-1 (AP-1) in human umbilical vein endothelial cells (HUVEC). The objective of this st...
Topics
- Activating Transcription Factor 2
- Animals
- Aorta
- Cattle
- Cell Division
- Cyclic AMP Response Element-Binding Protein
- Endothelium, Vascular
- Epoprostenol
- Gene Expression Regulation
- Genes, Immediate-Early
- Humans
- NF-kappa B
- Nuclear Proteins
- Phenotype
- Protein Kinase C
- Species Specificity
- Stress, Mechanical
- Time Factors