Article
Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells.
Journal of molecular and cellular cardiology - 1 Oct 2001
Cheng T H, Shih N L, Chen S Y, Loh S H, Cheng P Y, Tsai C S, Liu S H, Wang D L, Chen J J
Abstract excerpt
Endothelin-1 (Et-1) is a peptide synthesized by endothelial cells (ECs) both in culture and in vivo. Cyclic strain induces gene expression of Et-1, however, the molecular mechanisms remain unclear. Since cyclic strain induces a sustained increase in intracellular reactive oxygen species (ROS), we hypothesized that the ROS could be a modulator in strain-induced Et-1 gene expression. Human umbilical vein ECs...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.