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Article

Phylogenetic comparative mutational analysis of the base-pairing between RNase P RNA and its substrate.

RNA (New York, N.Y.) - 1 May 1996

Svärd S G, Kagardt U, Kirsebom L A

Abstract excerpt

We have studied the base-pairing between the 3'-terminal CCA motif of a tRNA precursor and RNase P RNA by a phylogenetic mutational comparative approach. Thus, various derivatives of the Escherichia coli tRNA(Ser)Su1 precursor harboring all possible substitutions at either the first or the second C of the 3'-terminal CCA motif were generated. Cleavage site selection on these precursors was studied using mutant...

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PMID: 8665413
PMCID: PMC1369387

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