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Article

Evidence against defective trans-Golgi acidification in cystic fibrosis.

The Journal of biological chemistry - 28 Jun 1996

Seksek O, Biwersi J, Verkman A S

Abstract excerpt

Defective organelle acidification has been proposed as a unifying hypothesis to explain the pleiotropic cellular abnormalities associated with cystic fibrosis. To test whether cystic fibrosis transmembrane conductance regulator (CFTR) participates in trans-Golgi pH regulation, intraluminal trans-Golgi pH was measured in stably transfected Swiss 3T3 fibroblasts (expressing CFTR or DeltaF508-CFTR) and...

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Source

Identifiers

PMID: 8663158
DOI: 10.1074/jbc.271.26.15542

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Evidence against defective trans-Golgi acidification in cystic fibrosis.PMID 8663158Read ↗

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GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.Semantic proximity Read ↗

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Selective activation of cystic fibrosis transmembrane conductance regulator Cl- and HCO3- conductances.Semantic proximity Read ↗

Role of CFTR in lysosome acidification.Semantic proximity Read ↗

Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages.Semantic proximity Read ↗

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SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis.Semantic proximity Read ↗

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