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Article

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.

Nature cell biology - 1 Oct 2008

Maeda Yusuke, Ide Toru, Koike Masato, Uchiyama Yasuo, Kinoshita Taroh

Abstract excerpt

The organelles within secretory and endocytotic pathways in mammalian cells have acidified lumens, and regulation of their acidic pH is critical for the trafficking, processing and glycosylation of cargo proteins and lipids, as well as the morphological integrity of the organelles. How organelle lumen acidification is regulated, and how luminal pH elevation disturbs these fundamental cellular processes, is...

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PMID: 18794847
DOI: 10.1038/ncb1773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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